HRD TEST PORTABLE

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HRD TEST PORTABLE

Portable HRD equipment gives an LCD readout of the hardness value. Another approach uses the change in resonant frequency of a body when it is embedded in the material. One such technique uses the measurement of the velocity of a body before and after hitting the component surface to calculate a hardness value. Techniques for portable HRD testers have been developed. Laboratory testers rely on measuring the relationship between load and the indentation in the surface produced by a ball, cone or pyramid applied to the surface (see Figure). In the laboratory, HRD is commonly performed using a Vickers or Rockwell hardness tester. HRD can show if a component material is changing properties during operation. Hardness is not a fundamental property of a material and is defined by the measurement technique applied. HRD is used to assess a materialвЂ™s resistance to abrasives, resistance to plastic deformation, its stren gth and brittleness or lack of d uctili ty. HRD вЂ“ Ha rdness Testing is the measurement of a materialвЂ™s resistance to penetration. Potential drop flaw detection and sizing.Here, we discuss the premise of HRD testing in HGSOC, current methodologies for HRD identification and their performance in the clinic, highlight upcoming strategies, and discuss the challenges faced in moving this field forward. It is thus critical that HRD testing is optimized to address the controversies of diverse HRD testing methodology, appropriate thresholds for HRD identification, and relevant timepoints for HRD testing, in order to realize the potential for PARPis to maximally benefit patients with HGSOC. In practice, this means that restoration of HRR through mechanisms of platinum and PARPi resistance are not adequately represented by genomic scar assays, and contribute toward discordance with clinical PARPi response, or lack-thereof. Yet despite the rapid maturation of this field, tumoral HRD status has been recognized to be dynamic over time and with treatment pressure. At present, clinical-grade assays such as mењњhoice CDx and FoundationOne CDx are approved companion diagnostics which can identify patients with HRD-positive HGSOC by diagnosing a вЂgenomic scarвЂ™ reflecting underlying genomic instability. Recent data have drawn attention to the assessment of homologous recombination DNA repair (HRR) as a prognostic and predictive biomarker in HGSOC, leading to increasing debate on the optimal means of defining and evaluating HRD, both genotypically and phenotypically. Poly(ADP-ribose) polymerase inhibitors (PARPis), developed based on the rationale of synthetic lethality that predicates antitumor efficacy in tumors harboring underlying HRD, now represents an important class of therapy for HGSOC. The recognition of homologous recombination deficiency (HRD) as a frequent feature of high-grade serous ovarian cancer (HGSOC) has transformed treatment paradigms.

Hrd test